Transcriptome signature of miRNA-26b KO mouse model suggests novel targets
نویسندگان
چکیده
منابع مشابه
Transcriptome-Wide Prediction of miRNA Targets in Human and Mouse Using FASTH
Transcriptional regulation by microRNAs (miRNAs) involves complementary base-pairing at target sites on mRNAs, yielding complex secondary structures. Here we introduce an efficient computational approach and software (FASTH) for genome-scale prediction of miRNA target sites based on minimizing the free energy of duplex structure. We apply our approach to identify miRNA target sites in the human...
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BACKGROUND Longstanding ulcerative colitis (UC) bears a high risk for development of UC-associated colorectal carcinoma (UCC). The inflammatory microenvironment influences microRNA expression, which in turn deregulates target gene expression. microRNA-26b (miR-26b) was shown to be instrumental in normal tissue growth and differentiation. Thus, we aimed to investigate the impact of miR-26b in in...
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ژورنال
عنوان ژورنال: BMC Genomic Data
سال: 2021
ISSN: 2730-6844
DOI: 10.1186/s12863-021-00976-1